范建华
发布时间:2024-02-09   访问次数:29769


范建华


生物工程专业:博士生导师/硕士生导师

生物学专业:博士生导师/硕士生导师

生物与医药专业(生物工程领域):博士生导师/硕士生导师



198412月生,江苏海门人,中共党员,教授,博士生导师。

入选上海市浦江人才计划(2018),上海市晨光计划2014),江苏省双创人才2023),美国斯坦福大学卡内基科学研究所访问学者(2016-2017)。获上海海洋科学技术奖青年科技创新奖2023)、上海市生物工程学会优秀青年科学家奖2022)。获必赢电子游戏官网青年五四奖章2023)、青年英才培育计划2020)、优秀研究生指导老师2022)、优秀研究生兼职辅导员2019)、校园新星2021)等荣誉称号。担任中国生物工程学会一碳生物技术专委会委员(2022-2026)、中国化工学会生物化工专业委员会青年学者工作委员会委员(2023-2027)、上海市生物工程学会一碳生物技术专委会委员(2023-2027)。

承担国家自然科学基金国家重点研发计划合成生物学专项973计划子课题、中央高校基本科研业务费专项基金、上海市自然科学基金、山东省自然科学基金重大基础研究项目等多个国家级/省部级项目。已在Biotechnology AdvancesTrends in Food Science and TechnologyChemical Engineering JournalPlant PhysiologyBiotechnology for BiofuelsBioresource TechnologyBioorganic Chemistry等专业领域Top期刊等杂志上发表论文50多篇,Google Scholar总被引用超过1700次,单篇最高引用超300次,入选ESI高被引论文1篇、热点论文1篇;申请发明专利26项,授权12项。

中国石油与化工教育教学优秀成果一等奖20202022),必赢电子游戏官网本科教学成果二等奖20192021),主持教育部产学合作协同育人项目20192021)。指导本科生获国际遗传工程机器大赛iGEM金奖及生物制造单项最佳奖2019);指导本科生获全国大学生生命科学竞赛一等奖20212项);指导研究生获中国互联网+”大学生创新创业大赛上海市金奖2021)、挑战杯中国大学生创业计划竞赛上海市银奖等省部级奖励(2022)。指导研究生获国家奖学金(5人次)、上海市优秀毕业生(5人次)、成思危名誉校长奖学金和校高水平论文奖等荣誉;指导本科生承担国家级/上海市级大学生创新创业训练计划十多项。

教育/工作经历

2024/01-至今

必赢电子游戏官网

教授,博士生导师

2022/03-2023/07

石河子大学化学化工学院

党委委员、副院长(援疆)

2015/01-2023/12

必赢电子游戏官网

历任讲师、副教授,硕导/博导

2016/10-2017/10

Stanford   UniversityCarnegie Institution for Science

访问学者

2012/12-2014/12

必赢电子游戏官网生物反应器工程国家重点实验室

师资博士后

2010/12-2012/06

中国科学院青岛生物能源与过程研究所

   联合培养

2009/03-2010/02

中国科学院遗传与发育生物学研究所

联合培养

2007/09-2012/11

必赢电子游戏官网

生物化工,硕博连读

2003/09-2007/07

必赢电子游戏官网

生物科学,本科

 

主要研究方向

1)生物转化与绿色低碳技术

主要针对富含生物活性物质和高效环境修复的微藻优良种质,重点探索营养与环境因素对微藻生长及代谢作用机制、微藻光合自养和光暗发酵过程中碳氮磷高效生物转化及优化调控技术,为微藻植物蛋白和生物活性物质生产(如藻胆蛋白、PUFAs、色素、多糖等)、环境治理(CO2减排和污染物降解)与生物质利用、生物饵料与饲料、生物能源的开发提供绿色低碳关键技术。

2)合成生物系统构建与应用

主要以微藻及蓝细菌等光合微生物为研究对象,基于功能基因组学、代谢途径解析与组装、合成生物技术等手段开发藻细胞底盘,建立成熟的表达系统/基因编辑体系(细胞核、叶绿体基因组),实现外源蛋白(如疫苗、工业酶、药用蛋白、抗体、细胞因子等)在藻细胞内高效表达,藉此推动微藻绿色细胞工厂相关技术的发展(如重组微藻疫苗、活细胞光-酶催化等),实现高值化利用。


学术兼职

1.  Frontiers in Marine Science副主编(SCI收录,Q1 Top期刊,2019-至今)

2.  Bioresources and Bioprocessing青年编委(SCI收录,Q22020-至今)

3.  Frontiers in Bioengineering and Biotechnology客座副主编(SCI收录,Q2),主持Novel insights into algal biology and biotechnology2017)、Advanced technologies and perspectives on sustainable microalgae production2020)、Microalgal production of omega fatty acids: present and future2022)专刊

4.  中国生物工程学会一碳生物技术专委会委员(2022-2026

5.  中国化工学会生物化工专业委员会青年学者工作委员会委员(2023-2027

6.  上海市生物工程学会一碳生物技术专委会委员(2023-2027

7.  美国植物生物学家学会(ASPB)会员(2015-)、中国藻业协会会员(2020-

8.  Nature CommunicationsNew PhytologistBiotechnology for BiofuelsBioresource TechnologyJournal of Agricultural and Food ChemistryBiotechnology JournalBiochemical Engineering JournalBriefings in BioinformaticsAlgal Research、生物工程学报、微生物学报等20多个期刊审稿人


承担教学任务

1.  上海市重点课程、专业必修课《分子生物学》(全英文,48学时,3学分);

2.  专业选修课《进化生物学》(32学时,2学分);

3.  专业必修课《生物化学实验》(32学时,1学分);

4.  公选课《国际遗传工程机器竞赛与合成生物技术》(16学时,1学分,团队教学);

5.  班导师,iGEM竞赛指导老师,Biomaker创新俱乐部指导老师,大创指导老师;


近年来发表论文(一作或通讯,中国科学院分区)

[1]  Ping Wu, Tianyouzi Hu, Liyun Sun, Jianhua Fan*. Efficient degradation of sulfadiazine by photosynthetic cyanobacteria Synechocystis sp. PCC 6803 coupling with recombinant laccase strategy. Chemical Engineering Journal, 2023, 474, 145974. IF15.10, 1top

[2] Cheng Chen, Qianwen Shi, Akang Tong, Liyun Sun, Jianhua Fan*. Screening of microalgae strains for efficient biotransformation of small molecular organic acids from dark fermentation biohydrogen production wastewater. Bioresource Technology, 2023, 390, 129872. IF11.39, 1top

[3]  Qianwen Shi#, Zuodong Zhou#, Zhiwei Hong, Zhi Yang, Zhengquan Gao, Liyun Sun*, Jianhua Fan*.Transcriptomics reveal how circadian regulation contributes to starch hyperaccumulation in marine alga Tetraselmis helgolandica. GCB Bioenergy, 2023, 15:1477-1493. IF5.59, 3

[4]  Liang Ji#, Sheng Qiu#, Zhiheng Wang, Chenni Zhao, Bo Tang, Zhengquan Gao, Jianhua Fan*. Phycobiliproteins from algae: Current updates in sustainable production and applications in food and health. Food Research International, 2023,167:112737. IF8.10, 1top

[5]  Sheng Qiu, Yuchen Yuan, Xiaoyi Li, Chenni Zhao, Yulong He, Bo Tang, Wenda Wang, Jianhua Fan*. Peridinin-chlorophyll-protein complex industry from algae: A critical review of the current advancements, hurdles, and biotechnological potential. Algal Research, 2023, 72, 103118. IF5.10, 2

[6]  Cheng Chen, Tao Tang, Qianwen Shi, Zuodong Zhou, Jianhua Fan*. The potential and challenge of microalgae as promising future food sources. Trends in Food Science and Technology, 2022, 126:99-112. IF15.29, 1topESI高被引、热点论文

[7]  Qianwen Shi, Cheng Chen, Tingwei He, Jianhua Fan*. Circadian rhythm promotes the biomass and amylose hyperaccumulation by mixotrophic cultivation of marine microalga Platymonas helgolandicaBiotechnology for Biofuels and Bioproducts, 2022, 15, 75. IF6.29, 2

[8] Liang Ji, Yueling Liu, Jianquan Luo, Jianhua Fan*. Freeze-thaw-assisted aqueous two-phase system as a green and low-cost option for analytical grade B-phycoerythrin production from unicellular microalgae Porphyridium purpureum. Algal Research, 2022, 67, 102831. IF5.1, 2

[9] Ke Ma, Lei Deng, Haizhen Wu*, Jianhua Fan*. Towards green biomanufacturing of high-value recombinant proteins using promising cell factory: Chlamydomonas reinhardtii chloroplast. Bioresources and Bioprocessing, 2022, 9, 83. IF4.60, 3

[10] Dongqing Zhou, Yeling Luo, Yingqiu Zhang, Chenni Zhao, Hui Wu*, Jianhua Fan*. Perturbing electron carriers of green algae Chlamydomonas reinhardtii for efficient physiological and metabolic regulation. Food Bioengineering, 2022, 1:148-158.

[11] Ping Wu, Zhaofei Zhang, Yeling Luo, Yunpeng Bai, Jianhua Fan*. Bioremediation of phenolic pollutants by algae - current status and challenges. Bioresource Technology, 2022, 350, 126930. IF11.39, 1top

[12] Ke Ma, Siwei Chen, Yue Wu, Yiting Ma, Haochen Qiao, Jianhua Fan*, Haizhen Wu*. Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology, 2022, 106: 773-788. IF5.00, 3

[13] Jianhua Fan, Yinghui Zhang, Ping Wu, Xiaoyan Zhang, Yunpeng Bai*. Enhancing cofactor regeneration of cyanobacteria for the light-powered synthesis of chiral alcohols. Bioorganic Chemistry, 2022, 118, 105477. IF5.10, 2top

[14] Jianhua Fan*, Qiuwen Bao, Ke Ma, Xiaofei Li, Jing Jia, Haizhen Wu*. Antioxidant and innate immunity of Danio rerio against Edwardsiella tarda in response to diets including three kinds of marine microalgae. Algal Research, 2022, 64, 102689. IF5.10, 2

[15] Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu*. Reprogramming the metabolism of Synechocystis PCC 6803 by regulating the plastoquinone biosynthesis. Synthetic and Systems Biotechnology, 2021, 4(6):351-359. IF4.80, 2

[16] Liang Ji, Shaohua Li, Cheng Chen, Haojie Jin, Haizhen Wu, Jianhua Fan*. Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation. Bioresources and Bioprocessing, 2021, 8, 73. IF4.60, 3

[17] Shaohua Li#, Jianke Huang#, Liang Ji, Cheng Chen, Ping Wu, Wei Zhang, Gaoyi Tan, Haizhen Wu, Jianhua Fan*. Assessment of light distribution model for marine red microalga Porphyridium purpureum for sustainable production in photobioreactor. Algal Research, 2021, 58, 102390. IF5.10, 2

[18] Qianwen Shi, Cheng Chen, Wei Zhang, Ping Wu, Meng Sun, Hui Wu, Haizhen Wu, Pengcheng Fu*, Jianhua Fan*. Transgenic eukaryotic microalgae as green factories: providing new ideas for the production of biologically active substances. Journal of Applied Phycology, 2021, 33:705-728. IF3.30, 3

[19] Ke Ma#, Qiuwen Bao#, Yue Wu, Siwei Chen, Shuxin Zhao, Haizhen Wu*, Jianhua Fan*. Evaluation of microalgae as immunostimulants and recombinant vaccines for disease prevention and control in aquaculture. Frontiers in Bioengineering and Biotechnology, 2020, 8, 590431. IF5.69, 3

[20] Shaohua Li, Liang Ji, Cheng Chen, Shuxin Zhao, Meng Sun, Zhengquan Gao, Haizhen Wu, Jianhua Fan*.Efficient accumulation of high-value bioactive substances by carbon to nitrogen ratio regulation in marine microalgae Porphyridium purpureum. Bioresource Technology, 2020, 309, 123362. IF11.39, 1top

[21] Shaohua Li#, Liang Ji#, Qianwen Shi#, Haizhen Wu, Jianhua Fan*. Advances in the production of bioactive substances from marine unicellular microalgae Porphyridium spp. Bioresource Technology, 2019, 292, 122048. IF11.39, 1top

[22] Lili Xu, Jianhua Fan*, Quanxi Wang*.Omics application of bio-hydrogen production through green alga Chlamydomonas reinhardtii. Frontiers in Bioengineering and Biotechnology, 2019, 7,  201. IF5.69, 3

[23] Lili Xu, Huawei Yong, Xiaomeng Tu, Quanxi Wang*, Jianhua Fan*. Physiological and proteomic analysis of Nostoc flagelliforme in response to alkaline pH shift for polysaccharide accumulation.Algal Research, 2019, 39, 101444. IF5.10, 2

[24] Pengfei Cheng, Chengxu Zhou, et al, Xiaojun Yan*, Jianhua Fan*. Comparative transcriptome analyses of oleaginous Botryococcus braunii race A reveal significant differences in gene expression upon cobalt enrichment. Biotechnology for Biofuels, 2018, 11, 333. IF6.29, 1top

[25] Lvhong Zheng, Xiaoyan Zhang, Yunpeng Bai*, Jianhua Fan*. Using algae cells to drive cofactor regeneration and asymmetric reduction for the synthesis of chiral chemicals.Algal Research, 2018, 35:432-438. IF5.10, 2

[26] Jianhua Fan*, Lvhong Zheng, Yunpeng Bai, Shai Saroussi, Arthur Grossman. Flocculation of Chlamydomonas reinhardtii with different phenotypic traits by metal cations and high pH. Frontiers in Plant Science, 2017, 8, 1997. IF5.59, 2top

[27] Jianhua Fan*, Lvhong Zheng. Acclimation to NaCl and light stress of heterotrophic Chlamydomonas reinhardtii for lipid accumulation. Journal of Bioscience and Bioengineering, 2017, 124(3):302-308. IF2.80, 3

[28] Conglin Run, Lei Fang, Jianhua Fan*, et al. Stable nuclear transformation of the industrial alga Chlorella pyrenoidosa. Algal Research, 2016, 17:196-201. IF5.10, 2

[29] Jianhua Fan*, Hui Xu, Yuanguang Li*. Transcriptome-based global analysis of gene expression in response to carbon dioxide deprivation in the green algae Chlorella pyrenoidosa. Algal Research, 2016, 16:12-19IF5.10, 2

[30] Jianhua Fan, Kang Ning, Xiaowei Zeng, et al, Jian Xu*, Yuanguang Li*. Genomic foundation of starch-to-lipid switch in oleaginous Chlorella spp. Plant Physiology, 2015, 169(4):2444-2461. IF7.40, 1top

[31] Jianhua Fan, Hui Xu, Yuanchan Luo, Minxi Wan, Jianke Huang, Weiliang Wang, Yuanguang Li*. Impacts of CO2 concentration on growth, lipid accumulation and carbon concentrating mechanism related genes expression in oleaginous Chlorella. Applied Microbiology and Biotechnology, 2015, 99(5):2451-2462. IF5.00, 3

[32] Jianhua Fan#, Yanbin Cui#, Minxi Wan, Weiliang Wang, Yuanguang Li*. Lipid accumulation and biosynthesis genes response of the oleaginous Chlorella pyrenoidosa under three nutrition stressors. Biotechnology for Biofuels, 2014, 7, 17. IF6.29, 1top

[33] Jianhua Fan, Yanbin Cui, Yang Zhou, Minxi Wan, Weiliang Wang, Jingli Xie, Yuanguang Li*. The effect of nutrition pattern alteration on Chlorella pyrenoidosa growth, lipid biosynthesis-related gene transcription. Bioresource Technology, 2014, 164:214-220. IF11.39, 1top

[34] Jianhua Fan#, Yanbin Cui#, Jianke Huang, Weiliang Wang, Weibo Yin, Zanmin Hu*, Yuanguang Li*. Suppression subtractive hybridization reveals transcript profiling of Chlorella under heterotrophy to photoautotrophy transition. PLoS One, 2012, 7:1-15. IF3.70, 3

[35] Jianhua Fan, Jianke Huang, Yuanguang Li*, Feifei Han, Jun Wang, Xinwu Li, Weiliang Wang, Shulan Li. Sequential heterotrophy-dilution-photoinduction cultivation for efficient microalgal biomass and lipid production. Bioresource Technology, 2012, 112:206-211. IF11.39, 1top


申请发明专利

1.  范建华, . 一种利用海洋绿藻青岛大扁藻积累淀粉的方法. 中国发明专利(授权), ZL 202111430978.8, 授权时间:2023725

2.  范建华, .一种转基因微藻及其在调控代谢产物合成中的应用. 中国发明专利(授权), ZL 202110303222.0, 授权时间:2023725

3.  范建华, . 培养红藻门单细胞海洋微藻生产生物活性成分的方法. 中国发明专利(授权)ZL 201910155145.1,授权时间:2022729

4.  范建华, . 用于甲藻高效生产高价值天然产物的培养基及其培养方法和装置. 中国发明专利,申请号:2023111837019, 申请时间:2023914

5. 范建华, . 一种利用甲藻高效低碳生产 PerCP 的方法. 中国发明专利,申请号:2023111837004, 申请时间:2023914

6.  范建华, . 一种从固氮蓝藻中分离纯化高纯度藻胆蛋白的方法及藻胆蛋白. 中国发明专利(授权)ZL 202110747801.4,申请时间:202172日,已转让

7.  范建华, . 一种高效分离纯化海洋微藻藻胆蛋白的方法及藻胆蛋白. 中国发明专利,申请号:202110408959.9, 申请时间:2021416

8. 范建华, . 一种广谱型微藻口服疫苗及其制备方法和应用. 中国发明专利,申请号:202010156447.3,申请时间:202039


承担科研项目

1.  上海市自然科学基金面上项目,2023.4-2026.3,资助编号:23ZR1415100,主持。

2.  上海市自然科学基金面上项目,2021.7-2024.6,资助编号:21ZR1416400,主持。

3.  必赢电子游戏官网“双一流建设项目,2023.1-2024.12,项目负责人。

4. 国家重点研发计划合成生物学专项青年项目,2020.1-2024.12,资助编号:2019YFA0906300,任务负责人。

5.  山东省自然科学基金重大基础研究项目,2019.12-2024.12,资助编号:ZR2019ZD17,课题负责人。

6. 国家重点研发计划合成生物学专项子课题,2020.11-2025.10,资助编号:2020YFA0907304,子课题负责人。

7.  南海海洋资源利用国家重点实验室开放课题,2019.1-2020.12,资助编号:2019002,主持。

8.  国家自然科学基金面上项目,2019.1-2022.12,资助编号:31872608,参与。

9.  上海市浦江人才计划,2018.9-2020.8,资助编号:18PJD008,主持。

10.  生物反应器工程国家重点实验室开放课题,2018.9-2020.8,资助编号:2018021,主持。

11.  上海市自然科学基金探索类项目,2018.6-2021.5,批准号:18ZR1410100,主持。

12.  上海市自然科学基金面上项目,2017.5-2020.4,批准号:17ZR1406700,主持。

13.  上海市晨光计划,2015.1-2017.12,资助编号:14CG27,主持。

14.  国家自然科学基金青年科学基金,2014.1-2016.12,批准号:31300295,主持。

15.  中国博士后科学基金,2013.6-2014.12,资助编号:2013M541483,主持。

16.  生物反应器工程国家重点实验室开放课题,2013.6-2015.5,资助编号:2013005,主持。

17.  中央高校基本科研业务费专项资金,2013.6-2015.5,资助编号:WF1314033,主持。

18.  973计划子课题,资助编号:2011CB2009032013.1-2015.8,子课题主持。

19.  国家自然科学基金青年科学基金,2014.1-2016.12,批准号:21306222,参与。

20. 中国博士后国际交流计划学术交流项目(8th Algal Biomass Summit美国圣地亚哥), 2014.10,主持。


联系方式

上海市梅陇路130365信箱,实验八楼415(办公室)、406(实验室);

电话:021-64252256E-mailjhfan@ecust.edu.cn